Efficacy of Large B-Cell Lymphoma Treatments
common.study.values.description
“A Study Comparing the Efficacy and Safety of Polatuzumab Vedotin With Rituximab-Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab-Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Diffuse Large B-Cell Lymphoma”
This Phase III, randomized, double-blind, placebo-controlled study will compare the efficacy, safety, and pharmacokinetics of polatuzumab vedotin plus R-CHP versus R-CHOP in participants with previously untreated diffuse large B-cell lymphoma (DLBCL).
common.study.values.location
participant.ui.study.affiliations-map.online-study.header-virtual
participant.ui.study.affiliations-map.online-study.text
common.study.values.methods
common.study.methods.has-drugs-yes
common.study.methods.is-healthy-yes
Drug - Polatuzumab Vedotin
Polatuzumab vedotin IV infusion will be administered as per the schedule specified in the respective arm.
Drug - Rituximab
Rituximab IV infusion will be administered as per the schedule specified in the respective arm.
Drug - Cyclophosphamide
Cyclophosphamide IV infusion will be administered as per the schedule specified in the respective arm.
Drug - Doxorubicin
Doxorubicin IV infusion will be administered as per the schedule specified in the respective arm.
Drug - Vincristine
Vincristine IV infusion will be administered as per the schedule specified in the respective arm.
Drug - Vincristine Placebo
Placebo matching to vincristine will be administered as per the schedule specified in the respective arm.
Drug - Prednisone
Prednisone PO will be administered as per the schedule specified in the respective arm.
Drug - Polatuzumab vedotin Placebo
Placebo matching to polatuzumab vedotin will be administered as per the schedule specified in the respective arm.
participant.views.study.view.additional
participant.views.study.view.scientific-title
A Phase III, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial Comparing the Efficacy and Safety of Polatuzumab Vedotin in Combination With Rituximab and CHP (R-CHP) Versus Rituximab and CHOP (R-CHOP) in Previously Untreated Patients With Diffuse Large B-Cell Lymphoma
common.study.values.clinical-trial-id
NCT03274492
participant.views.study.view.id
0dNwLe
