Effect of Heavy Alcohol Consumption on Liver Function
“Effect of Heavy Alcohol Consumption on Farnesoid X Receptor (FXR) Signaling”
The main purpose of this study is to see whether heavy drinking will interfere with a specific pathway, called FXR signaling in the liver. The abnormality of this pathway may lead to liver injury in some patients who drink heavily.
Drug - Placebo
1 tablet of placebo, taken orally daily with water, approximately 30 minutes prior to breakfast for 4 weeks.
Drug - 10 mg Obeticholic Acid (OCA)
10 mg Obeticholic Acid (OCA) Study medication will be administered orally, once daily, approximately 30 minutes prior to breakfast for 4 weeks.
Effect of Heavy Alcohol Consumption on Farnesoid X Receptor (FXR) Signaling