Low Dose Fat-Induced Insulin Resistance

Low Dose Fat-Induced Insulin Resistance

The primary goal of this study is to determine the dose of fatty acids that acutely induces mild insulin resistance in healthy volunteers. We hypothesize that a low-dose of fatty acid infusion (Intralipid/heparin) will cause a mild insulin resistance. The dose of fatty acid infusion that reliably causes mild insulin resistance will be selected for use in future studies.

Pharmaceutical medication involved
Patients and healthy individuals accepted

Drug - Intralipid, 20% Intravenous Emulsion

Fatty Acid Infusion, either in low-dose (30 ml/hr) or medium-dose (60 ml/hr)

A Dose Finding Study for Fat-Induced Insulin Resistance in Healthy Volunteers