Magnetic Resonance Elastography, High Intracranial Pressure

Evaluating Raised Intracranial Pressure Using MR Elastography

Investigators will compare magnetic resonance (MR) elastography measurements to other forms of noninvasive methods of detecting raised intracranial pressure, including optical coherence tomography (OCT) imaging measurements of the retinal nerve fiber layer (RNFL) and indirect signs of raised intracranial pressure on magnetic resonance imaging (MRI).

No pharmaceutical medication involved
Patients and healthy individuals accepted

Radiation - MR elastography

MR elastography image acquisition will be conducted on the Compact 3T MRI scanner using a modified single-shot spin-echo echo-planar imaging pulse sequence.

Radiation - MRI structural brain imaging

MRI structural brain imaging will be done on the Compact 3T MRI at the same time as MR elastography.

Procedure - Lumbar puncture

All patients with papilledema will get lumbar punctures with opening pressure as part of their work-up for papilledema. A small number of patients without increased intracranial pressure will receive a lumbar puncture.

Optical Coherence Tomography (OCT) imaging

Optical Coherence Tomography (OCT) imaging will measure the peripapillary retinal nerve fiber layer (RNFL) thickness measurements The images with enhanced depth imaging will be obtained to measure the Bruch's membrane orientation.

Radiation - Optic nerve B-scan ultrasound

Ultrasound will be used to measure the optic nerve sheath diameter 3 mm posterior to the posterior scleral surface.

Evaluating Raised Intracranial Pressure Using MR Elastography