Exercise and Traumatic Brain Injury

Effect of Exercise Training on Physical, Cognitive, and Behavioral Function in People With TBI

Background: - Traumatic brain injury (TBI) often causes problems with moving and balance, and thinking and emotions. Exercise can improve these things in people with other brain damage. Researchers want to look at the effect of exercise on these things in people with TBI. Objectives: - To study how head injuries affect the brain. To study if exercise can help some symptoms in people with TBI. These include problems thinking, balancing, and moving, and depression or anxiety. Eligibility: - People age between 18 and 79 : - Had a non-penetrating TBI at least 12 months ago. - Are physically inactive, but can stand and walk without help. Design: - Participants will be screened with medical history, physical exam, and blood and urine tests. They may have a balance test. - Participants will be assigned to a high-intensity or a lower-intensity exercise program. - The study is 6 months long. There will be 3 months with exercise on an elliptical machine and 3 months without exercise. - Participants will exercise for 30 minutes on an elliptical machine, 3 days per week for 3 months. - Participants will also have 3 outpatient testing visits lasting approximately 8 hours, once every 3 months. This visit will include: - Blood tests - Tests for memory, attention, and thinking - Tests of walking and balance - Questionnaires - An MRI: they will lie in a machine that takes pictures of their brain, while breathing regular air and air with more carbon dioxide - Test of physical fitness.

No pharmaceutical medication involved
Patients and healthy individuals accepted


Exercise training of different intensity

Effect of Exercise Training on Physical, Cognitive and Behavioral Function in Patients With Traumatic Brain Injury