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Mechanisms of Pharyngeal Collapse in Sleep Apnea, Study B

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Mechanisms of Pharyngeal Collapse in Sleep Apnea, Study B

In obstructive sleep apnea (OSA), the upper airway recurrently closes during sleep. The mechanisms that lead to airway closure are not completely understood. Some studies have shown that there is progressive narrowing of the pharyngeal airway across breaths during expiration (Progressive Expiratory Narrowing, PEN) preceding an obstructive apnea. The cause of PEN is unknown. The investigators will test if lung volumes and low respiratory drive play a role in PEN.

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No pharmaceutical medication involved common.study.methods.has-drugs-no
Patients and healthy individuals accepted common.study.methods.is-healthy-no

Induction of flow limitation

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Mechanisms of Pharyngeal Collapse in Sleep Apnea, Study B

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NCT01738009

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5eVv5e