common.study.topics.clinical

Effect of Statin Use on Aldosterone Secretion

common.study.values.description

Effect of Statin Use on Aldosterone Secretion

The purpose of this research protocol is to determine if the same effects are observed in vivo in humans through a randomized controlled study. Data regarding a novel mechanism of the widely used statin class of medications on the mineralocorticoid pathway would likely have significant clinical implications on the future management of hypertension and other cardiovascular disease given the known pleiotropy of aldosterone action.

common.study.values.location

participant.ui.study.affiliations-map.online-study.header-virtual

participant.ui.study.affiliations-map.online-study.text

participant.ui.study.affiliations-map.legend.locations participant.ui.study.affiliations-map.legend.selected

common.study.values.methods

Pharmaceutical medication involved common.study.methods.has-drugs-yes
Patients and healthy individuals accepted common.study.methods.is-healthy-no

Placebo

Placebo prepared by Investigation Drug Services at Brigham and Women's Hospital

Drug - Simvastatin

Simvastatin 40 mg daily

Drug - Pravastatin

Pravastatin 80 mg daily

participant.views.study.view.additional

participant.views.study.view.scientific-title

Effect of Statin Use on Aldosterone Secretion

common.study.values.clinical-trial-id

NCT02871687

participant.views.study.view.id

7ax5Bb