Microvascular Blood Flow and Metabolic Flexibility
“Microvascular Blood Flow and Metabolic Flexibility in Hispanics”
Microvascular insulin resistance has been shown to precede myocyte insulin resistance and impairments in metabolic function. However, there is no convincing data showing the relationship between impaired microvascular flow and impaired metabolic flexibility. Recent evidence exists that impaired microvascular blood flow in Caucasians directly contributes to impaired metabolic flexibility in Caucasians (under review), however there is no such evidence in Hispanics. Since there is a large disparity in cardiometabolic disease in Hispanics, this study aims to determine the role of impaired microvascular blood flow on impaired substrate oxidation switching (metabolic flexibility) in healthy people at risk for developing type 2 diabetes.
Diagnostic Test - Mixed meal challenge
We will conduct a traditional oral glucose tolerance test (OGTT), and compare microvascular and metabolic responses with mixed meal challenge (MMC). The procedures between the two are identical except for what is being consumed. In brief, the OGTT will be 75 g of glucose, and the MMC will be a protein shake consisting of 30g of protein, 5 g of fat, and 35g of carbohydrate. A fasting sample of blood will be collected, and the test drink (either OGTT or MMC) will be given. We will collect blood to ...read more on ClinicalTrials.org
Cardiometabolic Health in Adult Latinos in the Rio Grande Valley With and Without Specific Gene Mutations