Ketamine for Sedation in Outpatient Adult Endoscopy

Ketamine for Endoscopic Sedation in Outpatient Adult Endoscopy.

We will be investigating the use of ketamine in sedation for endoscopic procedures, specifically outpatient endoscopy including esophagoduodenoscopy (EGD) and colonoscopy. Participants will be randomized to one of two arms including conventional moderate sedation with midazolam and fentanyl or the ketamine arm. They will then undergo the planned procedure. Physicians preforming the procedure will be surveyed following the procedure and patients will be surveyed twice, once after meeting criteria for discharge on day of the procedure and a second time 48 hours following the procedure.

Pharmaceutical medication involved
Patients and healthy individuals accepted

Drug - Ketamine

Experimental arm for sedation.

Drug - Midazolam injection

Part of standard sedation regimen and anxiolysis and for minimization of emergence reaction

Drug - Fentanyl

Part of standard sedation regimen

Ketamine as a Sedation Adjunct for Endoscopic Procedures