Post-Traumatic Stress Disorder and Cardiovascular Disease
“Role of Sympathetic Overactivity and Angiotensin II in PTSD and CV”
The purpose of this study is to find out why patients with post-traumatic stress disorder (PTSD) have an increased risk for heart disease and high blood pressure later in life. A second purpose is to find out what causes PTSD patients to have high adrenaline levels during stress. This study will also test if a medicine called losartan improves high adrenaline levels in patients with PTSD and if a certain gene that has to do with high blood pressure might be associated with high adrenaline levels.
Procedure - Microneurography
Skin will be stimulated with a pencil-shaped electrode to find a certain nerve. Once the nerve is found, two tiny sterile wire needles (about the size of acupuncture needles) will be put in the skin. One needle is put just under the skin at a short distance away from the nerve, and the other one into the nerve. The needles are attached to a computer recorder to record the nerve activity. It may take up to one hour to get the needles in the right place. After the tiny needle is in the right place ...read more on ClinicalTrials.org
Behavioral - Combat virtual reality video clip
Subjects will watch a video clip of combat on a computer screen or wearing video goggles.
Procedure - Handgrip Exercise
Subjects will squeeze a hand dynamometer intermittently.
Procedure - Cold Pressor Test (CPT)
Subjects' hand will be submerged in cold water (~0-1Â°C) up to the wrist for 1 minute.
Drug - Sodium Nitroprusside (SNP)
Subjects will receive sodium nitroprusside 100 Âµg, which is bolused through an antecubital intravenous catheter.
Drug - Phenylephrine
Subjects will receive phenylephrine 150 Âµg, which is bolused through an antecubital intravenous catheter 60 seconds after the sodium nitroprusside bolus
Drug - Losartan
Subjects will receive Losartan 25 mg once a day orally up to 12 weeks
Drug - Atenolol
Subjects will receive Atenolol 25 mg once a day orally up to 12 weeks
Post-Traumatic Stress Disorder and Cardiovascular Disease Risk: Role of Sympathetic Overactivity and Angiotensin II