common.study.topics.clinical

Autonomic and Cytokines Profiles in Ulcerative Proctitis

common.study.values.description

Autonomic and Cytokines Profiles of Patients With Ulcerative Proctitis

1. To prove that patients with ulcerative proctitis and proctosigmoiditis have impaired autonomic functions, i.e. increased sympathetic activity and/or reduced vagal tone. 2. To demonstrate inflammatory cytokine imbalance, i.e., increased pro-inflammatory cytokines. Presence of these abnormalities would make patients with ulcerative proctitis and proctosigmoiditis good candidates for future sacral nerve stimulation therapy.

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No pharmaceutical medication involved common.study.methods.has-drugs-no
Patients and healthy individuals accepted common.study.methods.is-healthy-no

ECG recording, inflammatory cytokines, microbiota, ulcerative colitis disease activity index

In this study, an electrocardiogram signal will be recorded for 30 min in the fasting state, and blood samples for inflammatory cytokines analysis (7 ml) will be taken at the end of the ECG recording; fecal samples will be taken on the experimental day before the study. In addition, ulcerative colitis disease activity index will be assessed using the Mayo scoring system.

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Autonomic and Cytokines Profiles of Patients With Ulcerative Proctitis

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NCT03259659

participant.views.study.view.id

9av4rd