Dopamine D3 Receptors in Alcohol Use Disorders
common.study.values.description
“Exploring Regulation and Function of Dopamine D3 Receptors in Alcohol Use Disorders: A [11C]-(+)-PHNO Study”
There is a need to better understand the mechanisms underlying alcohol use and dependence in order to advance the clinical treatment of alcohol dependence. Here, the investigators will use Positron Emission Tomography to determine if there is an up-regulation of D3 receptors in the brains of subjects with alcohol use disorders. The investigators will also investigate the relationship between D3 binding and major phenotypes associated with alcohol use disorders, namely: alcohol cue induced craving and motivation to self-administer alcohol in the laboratory.
common.study.values.location
participant.ui.study.affiliations-map.online-study.header-virtual
participant.ui.study.affiliations-map.online-study.text
common.study.values.methods
common.study.methods.has-drugs-no
common.study.methods.is-healthy-yes
[11C]-(+)-PHNO PET scan
PET scan
Alcohol Self-Administration
Session for assessing motivation for consuming alcohol.
Craving Task
Cue exposure paradigm
MRI scan
MRI scan scan to analyze the PET data will be administered.
Neuropsychological Assessment
Cognitive questionnaires administered over course of study.
participant.views.study.view.additional
participant.views.study.view.scientific-title
Exploring Regulation and Function of Dopamine D3 Receptors in Alcohol Use Disorders: A [11C]-(+)-PHNO Study
common.study.values.clinical-trial-id
NCT03037060
participant.views.study.view.id
9avr0a
