Clinical Trial

Therapy After Mastectomy for Breast Cancer

Study Description

Hypofractionated Radiation Therapy After Mastectomy in Preventing Recurrence in Patients With Stage IIa-IIIa Breast Cancer

This randomized phase III trial studies how well hypofractionated radiation therapy works in preventing recurrence in patients with stage IIa-IIIa cancer who have undergone mastectomy. Hypofractionated radiation therapy delivers higher doses of radiation therapy over a shorter period of time and may kill more tumor cells that remain after surgery and have fewer side effects.


Locations Selected Location


No pharmaceutical medication involved No pharmaceutical medication involved
Recruiting patients only Recruiting patients only

Radiation - Hypofractionated Radiation Therapy

Undergo hypofractionated RT

Radiation - Radiation Therapy

Undergo RT

Questionnaire Administration

Ancillary studies

Quality-of-Life Assessment

Ancillary studies

Laboratory Biomarker Analysis

Correlative studies

Additional Information

Official Study Title

RT CHARM: Phase III Randomized Trial of Hypofractionated Post Mastectomy Radiation With Breast Reconstruction

Clinical Trial ID


ParticipAid ID