Therapy After Mastectomy for Breast Cancer

Hypofractionated Radiation Therapy After Mastectomy in Preventing Recurrence in Patients With Stage IIa-IIIa Breast Cancer

This randomized phase III trial studies how well hypofractionated radiation therapy works in preventing recurrence in patients with stage IIa-IIIa cancer who have undergone mastectomy. Hypofractionated radiation therapy delivers higher doses of radiation therapy over a shorter period of time and may kill more tumor cells that remain after surgery and have fewer side effects.

No pharmaceutical medication involved
Recruiting patients only

Radiation - Hypofractionated Radiation Therapy

Undergo hypofractionated RT

Radiation - Radiation Therapy

Undergo RT

Questionnaire Administration

Ancillary studies

Quality-of-Life Assessment

Ancillary studies

Laboratory Biomarker Analysis

Correlative studies

RT CHARM: Phase III Randomized Trial of Hypofractionated Post Mastectomy Radiation With Breast Reconstruction