Paired Associative Stimulation in Stroke

Paired Associative Stimulation in Stroke

Stroke is the third most common cause of death in the United States after heart disease and cancer, and the leading cause of long-term disability. This work will develop an innovative brain stimulation method (paired associative stimulation) which might set the stage for a new treatment for stroke rehabilitation.

No pharmaceutical medication involved
Patients and healthy individuals accepted

Device - Transcranial magnetic stimulation & median nerve stimulation

Paired associative stimulation (PAS) is a new technique where one pairs a peripheral stimulation with centrally applied transcranial magnetic stimulation (TMS), and produces plasticity, as measured by TMS MEP's. Currently PAS is performed with median nerve stimulation. PA25: The interval between median nerve stimulation and TMS was chosen to be 25 ms, which is called PAS25. 240 paired TMS and median nerve stimulation at a frequency of 0.2 Hz over 20 min. PAS10: 240 paired TMS and median nerve st more on

Paired Associative Stimulation Modulates Motor Excitability and Plasticity in Chronic Stroke Patients