Effect of Brussels Sprouts on the Metabolism

Glucobrassicin-Brussel Sprout Effect on D10 Phe Metabolism

To determine whether glucobrassicin-rich Brussels sprouts can favorably modify the metabolism of the polycyclic aromatic hydrocarbon deuterated phenanthrene ([D10]phe) in current and former smokers

Pharmaceutical medication involved
Patients and healthy individuals accepted

Brussel Sprouts

Subjects are given ~150 g of Brussels sprouts once daily for 7 consecutive days.

Drug - Deuterated Phenanthrene

Subjects are given 1 microgram of deuterated phenanthrene [D10]phe at baseline and after 7 days of Brussels sprout consumption. Urine is collected for 6 hours after each dose.

Assessing the Effect of Glucobrassicin-Rich Brussels Sprouts on the Metabolism of Deuterated Phenanthrene: Developing Food-Based Chemoprevention of Tobacco-Related Lung Cancer