Menopausal Sleep Fragmentation and Body Fat Gain

Menopausal Sleep Fragmentation and Body Fat Gain

This study aims to investigate the impact of menopause-related sleep fragmentation on metabolic biomarkers of body fat gain. The investigators hypothesize that experimental sleep fragmentation will result in an adverse leptin response as a metabolic biomarker for body fat gain.

Pharmaceutical medication involved
Patients and healthy individuals accepted

Drug - Leuprolide Acetate

one injection of open-label intramuscular dose of leuprolide (3.75-mg depot), a gonadotropin-releasing hormone agonist that rapidly suppresses estradiol and temporarily achieves ovarian suppression.

Fragmented sleep

Fragmented sleep will be experimentally induced.

Menopausal Sleep Fragmentation: Impact on Body Fat Gain Biomarkers in Women