Vitamin D as a Therapeutic Adjunct in the Treatment of ADHD
common.study.values.description
“Vitamin D as a Therapeutic Adjunct in the Stimulant Treatment of ADHD”
Specific Aim 1: As part of a within-subject, two-days, study design, to determine whether acute calcitriol (vs. placebo) pre-treatment is associated with greater amphetamine (Amp)-induced dopamine (DA) release in the caudate, putamen, ventral striatum (VST), and substantia nigra / ventral tegmental area (SN/VTA) of healthy human subjects. Specific Aim 2: To determine whether acute calcitriol (vs. placebo) pre-treatment is associated with better performance on a test of attention (e.g., the continuous Performance Task or CPT-AX), after treatment with amphetamine. Hypothesis: Investigators hypothesize that Subjects pre-treated with calcitriol will have faster reaction times/higher accuracy on the CPT-AX vs. subjects pre-treated with placebo, after treatment with amphetamine.
common.study.values.location
participant.ui.study.affiliations-map.online-study.header-virtual
participant.ui.study.affiliations-map.online-study.text
common.study.values.methods
common.study.methods.has-drugs-yes
common.study.methods.is-healthy-no
Procedure - Magnetic Resonance Imaging (MRI)
Magnetic resonance imaging (MRI) scans (3 T) will be collected in each subject for the purposes of excluding participants with anatomical abnormalities and anatomically co-registering PET and MRI for image analysis
Drug - Raclopride
Used as a tracer for in vivo imaging.
Dietary Supplement - calcitriol
three 0.5 mcg capsules
Drug - Placebo oral capsule
three 0.5 mcg capsules
Procedure - high-resolution research tomography
A functional imaging technique that is used to observe metabolic processes in the body.
Drug - Dextro Amphetamine
Dexedrine 0.3 mg/kg, to a maximum dose of 30 mg
participant.views.study.view.additional
participant.views.study.view.scientific-title
Vitamin D as a Therapeutic Adjunct in the Stimulant Treatment of ADHD: a Proof-of-concept Study of Stimulant-induced Dopamine Release Using [11C]-Raclopride PET in Healthy Humans
common.study.values.clinical-trial-id
NCT03103750
participant.views.study.view.id
Le3xxa
