The Role of Kisspeptin in the Reproductive System

Elucidating Kisspeptin Physiology by Blocking Kisspeptin Signaling

The investigators are looking for subjects to complete a study on the role of kisspeptin in the reproductive system. Kisspeptin is a naturally occurring hormone in humans that tells the body to produce other reproductive hormones. However, giving someone a continued amount of kisspeptin over a period of time can have the opposite effect and tell the body to, for a short time, stop making hormones needed for reproduction. By giving 24-hour infusions of kisspeptin, the investigators hope to learn more about the role kisspeptin has in the way bodies function normally and the role it has in conditions that affect the reproductive system.

Pharmaceutical medication involved
Patients and healthy individuals accepted

Drug - kisspeptin 112-121

24-h continuous intravenous infusion of kisspeptin 112-121 (12.5-40 mcg/kg/h), single intravenous dose of kisspeptin 112-121 (0.313-13.19 mcg/kg)

Drug - GnRH

Single intravenous dose of GnRH (2.5-250 ng/kg)

Elucidating Kisspeptin Physiology by Blocking Kisspeptin Signaling