“The Use of Oral Naloxone to Prevent Post Spinal Fusion Ileus”
Postoperative ileus and opioid induced constipation are well-known post-operative complications. Previously, research has shown that using peripherally acting opioid antagonists can help alleviate the condition. There has not been a prospective study to investigate whether use of peripherally acting opioid antagonists are effective in preventing post-operative ileus in patients having spinal fusion surgeries.
Drug - Naloxone
Blinding/labeling/preparation of agents: No blinding is required in this study. The study drug will be prepared, unit dose labelled, and patient labelled according to institutional protocols. Storage: Secured at room temperature in the central pharmacy then dispensed as a patient specific supply and stored at room temperature the automated dispensing cabinet. No more than a 24 hour supply will be dispensed at any given time. Administration: 1 mg/ml oral solution administered enterally (oral, nas ...read more on ClinicalTrials.org
The Use of Oral Naloxone to Prevent Post Spinal Fusion Ileus