Dietary Prevention of Type 2 Diabetes
common.study.values.description
“The TCF7L2 Gene: Dietary Prevention of T2DM”
Nutrients and chemicals in food are able to regulate expression of genetic elements. Gene-nutrient interaction in response specific diets can increase an individual's risk, shifting the individual from health toward the development of chronic disease. The Transcription Factor 7 Like 2 (TCF7L2) gene may either put individuals at risk for or protect from Type 2 diabetes mellitus in the presence of certain foods. The main purpose of this four-week study is to examine diet-induced gene-nutrient interaction, with a focus on glucose, insulin, inflammation (CRP) and the plasma metabolome in individuals who have either the CC or the TT form of the rs7903146 single nucleotide polymorphism (SNP) (C/T) within the TCF7L2 gene. The (2) one-week study diets, one Mediterranean diet (MedDiet) based and the other low-fat based will be separated by a (1) week return to a regular habitual diet.
common.study.values.location
participant.ui.study.affiliations-map.online-study.header-virtual
participant.ui.study.affiliations-map.online-study.text
common.study.values.methods
common.study.methods.has-drugs-no
common.study.methods.is-healthy-no
Mediterranean Diet
Participants will receive meals traditionally consumed in Mediterranean countries
Low-fat diet
Participants will receive meals with a low content of total fat.
participant.views.study.view.additional
participant.views.study.view.scientific-title
The TCF7L2 Gene: Nutrigenomics and Dietary Prevention of Type 2 Diabetes
common.study.values.clinical-trial-id
NCT03458494
participant.views.study.view.id
PdRpYa
