Dietary Prevention of Type 2 Diabetes

The TCF7L2 Gene: Dietary Prevention of T2DM

Nutrients and chemicals in food are able to regulate expression of genetic elements. Gene-nutrient interaction in response specific diets can increase an individual's risk, shifting the individual from health toward the development of chronic disease. The Transcription Factor 7 Like 2 (TCF7L2) gene may either put individuals at risk for or protect from Type 2 diabetes mellitus in the presence of certain foods. The main purpose of this four-week study is to examine diet-induced gene-nutrient interaction, with a focus on glucose, insulin, inflammation (CRP) and the plasma metabolome in individuals who have either the CC or the TT form of the rs7903146 single nucleotide polymorphism (SNP) (C/T) within the TCF7L2 gene. The (2) one-week study diets, one Mediterranean diet (MedDiet) based and the other low-fat based will be separated by a (1) week return to a regular habitual diet.

No pharmaceutical medication involved
Patients and healthy individuals accepted

Mediterranean Diet

Participants will receive meals traditionally consumed in Mediterranean countries

Low-fat diet

Participants will receive meals with a low content of total fat.

The TCF7L2 Gene: Nutrigenomics and Dietary Prevention of Type 2 Diabetes