common.study.topics.clinical

Hormonal Mechanisms of Sleep Restriction - Axis Study

common.study.values.description

“Hormonal Mechanisms of Sleep Restriction - Axis Study”

The purpose of this study is to 1) determine how hypothalamic-pituitary-adrenal axis (HPA axis) activation occurs with sleep restriction 2) evaluate how hypothalamic-pituitary-gonadal axis (HPG axis) deactivation occurs with sleep restriction. The investigator will also examine the cognitive function associated with sleep restriction, including food intake and food cravings.

common.study.values.location

participant.ui.study.affiliations-map.online-study.header-virtual

participant.ui.study.affiliations-map.online-study.text

participant.ui.study.affiliations-map.legend.locations participant.ui.study.affiliations-map.legend.selected

common.study.values.methods

Pharmaceutical medication involved common.study.methods.has-drugs-yes
Patients and healthy individuals accepted common.study.methods.is-healthy-no

Drug - Ketoconazole Pill

Ketoconazole pill is taken 4 times per Inpatient Stay

Drug - Ganirelix

Ganirelix subcutaneous injection is administered twice per Inpatient Stay

Drug - Dexamethasone

Dexamethasone Pills is taken twice per Inpatient Stay

Drug - Dexamethasone Injection

Dexamethasone IV injection is given twice per Inpatient Stay

Drug - Cosyntropin Injectable Product

cosyntropin injection is given twice per Inpatient Stay

Drug - Recombinant Human Luteinizing Hormone

Leutinizing-Releasing Hormone is given 6 IV infusion pulses per Inpatient Visit

Drug - Hydrocortisone Injection

Hydrocortisone IV push is given twice per Inpatient Visit

Drug - Gonadorelin

Gonadorelin IV injection is given twice per Inpatient Stay

Drug - Corticorelin

Corticorelin IV injection is given twice per Inpatient Stay

Drug - Placebo oral capsule

Placebo for ketoconazole are given 4 times per Inpatient Stay

Drug - Saline Solution

Saline Solution (Placebo) for Dexamethasone IV injection or hydrocortisone IV injection given up to four times per Inpatient Stay

Drug - Saline Solution for Injection

Saline Solution (placebo) for ganirelix subcutaneous injection

participant.views.study.view.additional

participant.views.study.view.scientific-title

Hormonal Mechanisms of Sleep Restriction - Axis Study

common.study.values.clinical-trial-id

NCT03142893

participant.views.study.view.id

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