Eligibility Details:
Inclusion Criteria for Women with Stage I - III Breast Cancer:
- Stage I-III female breast cancer (including inflammatory and newly diagnosed or
locally recurrent breast cancer) but not metastatic breast cancer being treated with
curative intent
- > 18 years old
- Scheduled to receive chemotherapy
- Able to hold breath for 10 seconds
- ECOG performance status 0 -2
- Able to walk at least 2 blocks without chest pain, dyspnea, shortness of breath or
fainting
- Able to exercise on a treadmill or stationary cycle
- Participants in other ongoing clinical trials are eligible for this study
Exclusion Criteria for Women with Stage I-III Breast Cancer:
- Those with ferromagnetic cerebral aneurysm clips or other intracranial metal;
pacemakers, defibrillators, functioning neurostimulator devices or other implanted
non-compatible MRI devices
- If previously measured, known LVEF <50%
- Symptomatic claustrophobia
- Unable to provide informed consent
- At the beginning of the study, pregnant women and women who are breast-feeding will
not be enrolled.
- Severe pulmonary hypertension
- Within the past 6 months:
- Acute pulmonary embolus
- Deep vein thrombosis
- Within the past month:
- Heart attack
- Unstable or stable angina (cardiac chest pain)
- Left main coronary artery disease
- Symptomatic heart failure
- Uncontrolled hypertension (SBP > 180 mm Hg or DBP > 100mm Hg)
- Severe valvular heart disease
- Uncontrolled metabolic disease (diabetes with fasting BS >300 mg/dl,
thyrotoxicosis, myxedema)
- Aortic aneurism (>45 mm diameter) or aortic dissection
- Uncontrolled slow or fast heart rhythm causing symptoms or hemodynamic compromise
- Hypertrophic obstructive cardiomyopathy
- Patient does not understand English
Inclusion Criteria for Women Free of Cancer for Comparison:
- Healthy female without known coronary artery disease > 18 years old
- Able to hold breath 10 seconds
- ECOG performance status = 0 or 1
- Able to walk at least 2 blocks without chest pain, dyspnea, shortness of breath or
fainting
- Able to exercise on a treadmill or stationary cycle
- No personal history of cancer other than superficial skin cancers
- Has never received chemotherapy, radiation therapy, immunotherapy, or had breast
cancer related surgery
- If previously measured, LVEF ≥ 50%
Exclusion Criteria for Women Free of Cancer for Comparison:
- Inflammatory conditions such as lupus or inflammatory bowel disease
- Overt coronary artery disease or heart failure
- Those with ferromagnetic cerebral aneurysm clips or other intracranial metal;
pacemakers, defibrillators, functioning neurostimulator devices or other implanted
non-compatible MRI devices
- Symptomatic claustrophobia
- Unable to provide informed consent
- At the beginning of the study, pregnant women or women who are breast feeding will not
be enrolled.
- Severe pulmonary hypertension
- Within the past 6 months:
- Acute pulmonary embolus
- Deep vein thrombosis
- Within the past month:
- Heart attack
- Unstable or stable angina (cardiac chest pain)
- Left main coronary artery disease
- Symptomatic heart failure
- Uncontrolled hypertension (SBP > 180 mm Hg or DBP > 100mm Hg)
- Severe valvular heart disease
- Uncontrolled metabolic disease (diabetes with fasting BS >300 mg/dl,
thyrotoxicosis, myxedema)
- Aortic aneurism (>45 mm diameter) or aortic dissection
- Uncontrolled slow or fast heart rhythm causing symptoms or hemodynamic compromise
- Hypertrophic obstructive cardiomyopathy
- Patient does not understand English
common.study.methods.has-drugs-no
common.study.methods.is-healthy-no
