Limb Ischemia Preconditioning in Subarachnoid Hemorrhage
“Preconditioning With Limb Ischemia for Subarachnoid Hemorrhage”
In remote preconditioning, ischemia in one organ protects distant organs from ischemic insults. e.g. brief induced limb ischemia protects the brain from an otherwise more severe stroke. The investigators propose a study of limb preconditioning in subjects with subarachnoid hemorrhage who are at high risk of cerebral ischemia in the first 2 weeks after hemorrhage. The investigators have previously shown that 3x 10min leg conditioning cycles are tolerated and appear safe. The investigators are now continuing to assess the safety of the intervention by enrolling an additional 60 patients.
ischemic conditioning group
application of a blood pressure cuff around a leg and inflating the cuff to 200mmHg to induce limb ischemia for 10min followed by 5min reperfusion. this will be done for 3 cycles every 24-48hours during the first 14 days after subarachnoid hemorrhage
Remote Ischemic Preconditioning to Ameliorate Delayed Ischemic Neurological Deficit After Aneurysmal Subarachnoid Hemorrhage: a Safety and Feasibility Study