Immunologic Profile of Chronically Photodamaged Skin

Immunologic Profile of Chronically Photodamaged Skin

Chronically photodamaged skin is visually characterized by dryness, wrinkles, brown spots, leathery appearance, etc. This happens as a result of excessive exposure to UV light from the sun. While the sun's exposure leaves the skin's surface visibly changed, the skin's unseen immune system may also be permanently altered as a result of the exposure, making it more likely to develop a variety of skin cancers and infections. This study will examine the lasting changes in the immune system of the skin caused by UV exposure. Investigators will stimulate different aspects of the skin's immune system by giving an injection of Candida Albicans (CANDINAR) and histamine phosphate (HISTATROLAR), topical applications of imiquimod 5% cream (ALDARAAR) and performing a tape stripping procedure with adhesive tape. The use of Candida Albicans (CANDINAR), histamine phosphate (HISTATROLAR), and tape stripping are common procedures in clinical settings to stimulate skin desired skin responses. Imiquimod 5% cream (ALDARAAR) is an FDA-approved drug for the treatment of basal cell carcinomas, actinic keratoses and genital warts. Investigators will compare the reaction of the skin's immune system on a cellular level from skin normally exposed to the sun exposure to an area normally hidden from sun exposure.

No pharmaceutical medication involved
Patients and healthy individuals accepted

Biological - Candida albicans antigen

0.1 milliliter (mL) injection into superficial dermis making small bleb at Baseline Visit.

Biological - histamine phosphate

0.01 milliliter (mL) of histamine phosphate injected into the superficial dermis making a small bleb at Baseline Visit.

Biological - imiquimod 5% cream

Pea sized amount of 5% cream to be applied to designated areas once daily for 4 days, beginning at Baseline Visit.

Procedure - Tape Stripping

At Baseline Visit, adhesive tape firmly applied to designated area for 2 seconds, then removed. Procedure repeated between 20 and 50 times until skin is slightly red and tacky.

Immunologic Profile of Chronically Photodamaged Skin