common.study.topics.clinical

Neural Correlates of Emotion in Depression

common.study.values.description

The Effect of Cortisol Administration on Neural Correlates of Emotion in Depression

There is good evidence to suggest that the pathological version of sadness that people with Major Depression experience could be caused by the failure of the hormone cortisol to properly inhibit sadness-related brain activity in the subgenual cingulate cortex. This project investigates if the subgenual cingulate cortex has become insensitive to cortisol in patients with depression and tests for variants of the cortisol receptor genes that could predispose individuals to develop cortisol insensitivity.

common.study.values.location

participant.ui.study.affiliations-map.online-study.header-virtual

participant.ui.study.affiliations-map.online-study.text

participant.ui.study.affiliations-map.legend.locations participant.ui.study.affiliations-map.legend.selected

common.study.values.methods

Pharmaceutical medication involved common.study.methods.has-drugs-yes
Patients and healthy individuals accepted common.study.methods.is-healthy-no

Drug - Hydrocortisone acetate

Drug - Placebo

participant.views.study.view.additional

common.study.values.clinical-trial-id

NCT02837432

participant.views.study.view.id

Rb427e