Effects of Pregnenolone on Perceived Social Isolation
Study Description
“Effects of Pregnenolone on Perceived Social Isolation”
No studies to date have examined the effects of pregnenolone on hypervigilance for social threat in individuals with perceived social isolation (PSI). We therefore are conducting a double-blind randomized research study combining three validated behavioral paradigms on social threat attention, perception of others, and emotion regulation with high-density electrical neuroimaging to probe the neuro-circuitry of social threat processing in young adults high in perceived social isolation two hours after the oral administration of 175mg pregnenolone (N = 24), 400mg of pregnenolone (N = 24), or placebo (N = 24). Such research has the potential to yield important insights into the neurobehavioral mechanisms of pregnenolone on hypervigilance for social threat and perception of others--- a first key step toward the development of adjunctive pregnenolone therapy in individuals with PSI.
Location
Methods
Pharmaceutical medication involved
Patients and healthy individuals accepted
Drug - Pregnenolone 175mg
Single Dose 175mg
Drug - Pregnenolone 400mg
Single Dose 400mg
Drug - Placebo
Single Dose
Additional Information
Official Study Title
Effects of Pregnenolone on Perceived Social Isolation: A Double-blind Randomized Electrical Neuroimaging Study
Clinical Trial ID
NCT02826577
ParticipAid ID
YaOGRa
