common.study.topics.clinical

Hookworm Vaccine Assessed by Controlled Challenge Infection

common.study.values.description

Efficacy of Na-GST-1/Alhydrogel Hookworm Vaccine Assessed by Controlled Challenge Infection

This study evaluates the efficacy, safety and immunogenicity of different formulations of the Na-GST-1 hookworm vaccine using a controlled human hookworm infection model in healthy, hookworm-naive adults.

common.study.values.location

participant.ui.study.affiliations-map.online-study.header-virtual

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Pharmaceutical medication involved common.study.methods.has-drugs-yes
Patients and healthy individuals accepted common.study.methods.is-healthy-no

Biological - Na-GST-1/Alhydrogel

Recombinant ˆNecator americanusˆ Glutathione-S Transferase adjuvanted with Alhydrogel

Biological - Na-GST-1/Alhydrogel + CPG 10104

Recombinant ˆNecator americanusˆ Glutathione-S Transferase adjuvanted with Alhydrogel and co-administered with CPG 10104, a synthetic oligodeoxynucleotide

Biological - Na-GST-1/Alhydrogel + GLA-AF

Recombinant ˆNecator americanusˆ Glutathione-S Transferase adjuvanted with Alhydrogel and co-administered with an aqueous formulation of Glucopyranosyl-Lipid A (GLA-AF)

Biological - Placebo

Physiological sterile saline solution

Drug - Albendazole

Treatment with 3 daily oral doses of 400 mg albendazole at end of study.

Necator americanus Larval Inoculum

50 infectious Necator americanus larvae applied via dermal application (challenge infection).

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Phase 2 Study to Assess the Safety, Efficacy and Immunogenicity of Na-GST-1/Alhydrogel Co-administered With Different Toll-Like Receptor Agonists in Hookworm- Naïve Adults

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NCT03172975

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YaOvpe