Cold Apheresis Platelets in PAS
common.study.values.description
“Cold Apheresis Platelets in PAS”
This is a platelet transfusion study. The purpose of this study is to measure the life span and quality of platelets stored in a refrigerator. Participants will give platelets by apheresis. Platelets will be stored for 3 -20 days. A small portion of the subject's own stored platelets will be tagged with a radioactive isotope and infused back into the participant. This will enable us to track how many transfused platelets survive after storage in the refrigerator.
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Procedure - Apheresis platelet collection
A single apheresis platelet unit will be collected from a healthy adult volunteer subject using the Trima Accel® Automated Blood Collection System. Concurrent plasma will be collected.
Refrigerated storage of apheresis platelets in PAS/plasma
The apheresis platelet unit will be stored, without agitation, at 4°C, for up to 20 days.
Radiation - Infusion of aliquot of autologous radiolabeled platelets
Fresh and stored aliquots will be labeled with Indium-111. We are administering ≤30 microcuries in both infusions for a total dose of 0.8 mSv.
In vitro tests
Tests to evaluate platelet function will be performed on the platelet unit on day of collection and end of storage
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Cold Apheresis Platelets in PAS
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NCT02754414
participant.views.study.view.id
Yerq2d
