common.study.topics.clinical

MRI Imaging Effects of Cannabis Smoking

common.study.values.description

Longitudinal Study of Xenon-129 MRI Imaging Effects of Cannabis Smoking

This is a longitudinal study of the long-term health impact of cannabis smoking on the lungs. Participants will be followed over a period of 10 years, and impacts of cannabis smoking on the lungs will be measured with magnetic resonance imaging (MRI) using hyperpolarized xenon-129 gas, pulmonary function tests, exercise capacity, computed tomography images and questionnaires.

common.study.values.location

participant.ui.study.affiliations-map.online-study.header-virtual

participant.ui.study.affiliations-map.online-study.text

participant.ui.study.affiliations-map.legend.locations participant.ui.study.affiliations-map.legend.selected

common.study.values.methods

No pharmaceutical medication involved common.study.methods.has-drugs-no
Patients and healthy individuals accepted common.study.methods.is-healthy-no

Diagnostic Test - Cardiopulmonary exercise testing (CPET)

Participants <35 will perform cardiopulmonary exercise testing as a measure of exercise capacity

Diagnostic Test - Sputum analysis

Participants will provide a sputum sample that will be analysed for eosinophils

Diagnostic Test - Blood analysis

Participants will have their blood drawn and analysed for eosinophil count.

Diagnostic Test - Hyperpolarized Xenon-129 MRI of the lungs

Participants will be imaged using MRI using hyperpolarized xenon-129 gas as a contrast gas

Diagnostic Test - Computed Tomography (CT)

Participants will undergo a CT scan of the thoracic cavity

Diagnostic Test - Pulmonary Function Tests (PFTs)

Participants will have their lung function evaluated using PFTs

Diagnostic Test - Six Minute Walk Test (6MWT)

Participants >35 years of age will perform the six minute walk test as a measure of exercise capacity

participant.views.study.view.additional

participant.views.study.view.scientific-title

Longitudinal Study of Xenon-129 MRI Imaging of Effects of Cannabis Smoking on Lung Structure and Function

common.study.values.clinical-trial-id

NCT03909477

participant.views.study.view.id

aAD7je