common.study.topics.clinical

Vasodilation in Young Adults

common.study.values.description

Pyridoxine, P2 Receptor Antagonism, and ATP-mediated Vasodilation in Young Adults

Previous research has identified adenosine triphosphate (ATP) as an important vasodilator that is released from red blood cells during exercise and exposure to hypoxic environments in adult humans. Further, older adults appear to have lower blood flow during both of these stressors and also have lower amounts of ATP released from their red blood cells. However, the contribution of ATP to vasodilation in response to exercise and hypoxia is currently unknown due to the lack of an effective ATP receptor antagonist. We aim to determine whether Vitamin B6 or its metabolite, Pyridoxal-5-Phosphate (PLP) is an effective ATP receptor antagonist.

common.study.values.location

participant.ui.study.affiliations-map.online-study.header-virtual

participant.ui.study.affiliations-map.online-study.text

participant.ui.study.affiliations-map.legend.locations participant.ui.study.affiliations-map.legend.selected

common.study.values.methods

Pharmaceutical medication involved common.study.methods.has-drugs-yes
Patients and healthy individuals accepted common.study.methods.is-healthy-no

Drug - Adenosine

See arm/group descriptions

Drug - Vitamin B 6

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Drug - Pyridoxal 5'-Phosphate

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Drug - Adenosine Triphosphate

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Drug - Acetylcholine

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Drug - Sodium Nitroprusside

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Drug - Adenosine Diphosphate

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Drug - Adenosine Monophosphate

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Drug - Uridine Triphosphate

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participant.views.study.view.additional

participant.views.study.view.scientific-title

Pyridoxine, P2 Receptor Antagonism, and ATP-mediated Vasodilation in Young Adults

common.study.values.clinical-trial-id

NCT03738943

participant.views.study.view.id

aKrYne