Probiotics and Capsaicin Evoked Coughs
common.study.values.description
“Probiotics and Capsaicin Evoked Coughs”
Cough in asthma is a very common and troublesome symptom in asthma, which predicts severity and poor prognosis. Previous studies have shown that asthmatics have an exaggerated cough response to capsaicin. Currently available asthma treatment is not designed to target the cough reflex directly, so this presents an unmet need for patients. The treatment being tested in this study is the commercially available over the counter oral probiotic BioGaiaAR DSM17938. Based on clinical and pre-clinical evidence, it is hypothesized that TRPV1 antagonism with BioGaiaAR DSM17938 will result in a reduction in capsaicin evoked coughs in patients with asthma.
common.study.values.location
participant.ui.study.affiliations-map.online-study.header-virtual
participant.ui.study.affiliations-map.online-study.text
common.study.values.methods
common.study.methods.has-drugs-no
common.study.methods.is-healthy-yes
Dietary Supplement - BioGaia-DSM17938
2mL per day (1x10^9 CFU) per day taken orally for 28 days
Placebo Comparator: Placebo Control
2mL per day of placebo formulation taken orally for 28 days
participant.views.study.view.additional
participant.views.study.view.scientific-title
A Double-Blind Randomized Placebo Controlled Trial Investigating the Effects of DSM17938 on Capsaicin Evoked Coughs
common.study.values.clinical-trial-id
NCT03603522
participant.views.study.view.id
aOY7Yd
