Testing Experimental Medication

Eligibility Details: Inclusion Criteria - The subject has a BMI of 18 to 40 kg/m2, inclusive, at screening. - The subject is able to provide written informed consent. For healthy subjects only : The subject has normal renal function as determined by eGFR and calculated using the MDRD formula, or by 24-hour urine creatinine clearance (CLcr) corrected for body size. For subjects with renal impairment only : The subject has mild, moderate, or severe renal impairment as determined by eGFR and calculated using the MDRD formula. Exclusion Criteria - The subject has a history or clinical manifestations of a significant neurological, cardiovascular, endocrine, gastrointestinal, pulmonary, hematologic, immunologic, or psychiatric disease that would preclude study participation, as judged by the investigator. - The subject has nephrotic syndrome, defined as serum albumin <3.0 g/dL and urine protein/creatinine ratio >350 mg/mmol (as an estimate of approximate proteinuria of >3.5 g/day) at screening.