Deep Brain Stimulation for Morbid Obesity

Eligibility Details: Inclusion Criteria: 1. Female or Male patients between age 20-60 2. Diagnosis of Morbid Obesity (defined as a BMI>40kg/m2 or BMI>35 with 1 obesity related comorbidity) OR a diagnosis of Binge Eating Disorder not responsive to recommended treatments (as defined by the DSM-5) 3. Failure or non eligibility of bariatric surgery with <50% of excess weight loss, with or without BMI>35 kg/m2, at 18 months or more after the operation; OR diagnosis of binge eating disorder for over 18 months 4. Diagnosis of food dependence via Yale Food Addiction Scale (YFAS) criteria 5. Normal neurological exam 6. Normal head CT scan and cerebral MRI 7. Patient informed and able to give written consent 8. Able to comply with all testing, follow-ups and study appointments and protocols Exclusion Criteria: 1. Active neurologic disease such as epilepsy 2. Alcohol or substance dependence or abuse in the last 6 months, excluding caffeine and nicotine 3. Any contraindication to magnetic resonance imaging (MRI) or positron emission tomography (PET) scanning 4. Likely to relocate or move during the study's one year duration 5. Presence of cardiac arrhythmias, or other cardiac, respiratory, renal or endocrine conditions as a result of morbid obesity, that will result in significant risk from a surgical procedure. 6. Presence of epilepsy, stroke or degenerative disorder of the nervous system 7. Pregnancy