Eligibility Details:
Inclusion Criteria:
- Men and Women aged 21-50 years
- Willing to take isolated xanthohumol as a dietary supplement for 8 weeks
- Willing to have blood drawn semi-weekly and to fast for 10-12 hours before blood draws
- Willing and able to collect semi-weekly stool samples at home
- Able to speak, read, and understand English
- Must be able to provide written informed consent
- Non-smokers (including tobacco and Cannabis products, combusted or vaporized)
Exclusion Criteria:
- History of any chronic disease including, but not limited to: diabetes (type 1 or 2);
uncontrolled hypertension; coronary artery disease resulting in angina; cardiovascular
disease requiring percutaneous coronary intervention (PCI), bypass, or past myocardial
infarction or stroke; blood disease including current anemia; cancer (except
non-melanoma skin cancer) within the last year or still requiring chemotherapy or
hormonal therapy; chronic kidney disease; liver disease including viral hepatitis,
non-alcoholic fatty liver disease, or alcoholic hepatitis/cirrhosis; any
immunocompromising condition including human immunodeficiency virus/acquired
immunodeficiency syndrome or organ transplant requiring anti-rejection medications;
chronic osteoarthritis requiring joint replacement or daily use of NSAIDs; chronic
endocrine condition including but not limited to: Cushing's, Addison's, Hashimoto's
thyroiditis, Grave's disease, etc.
- Body Mass Index (BMI) less than 20 (underweight) or greater than 30 (obese)
- Consumption of more than 1 microbrew beer per day
- Use of NSAIDs more than once per week for headaches, routine aches/pains, etc.
- Use of any prescription drugs, including oral contraceptives (due to potential
interference with mechanisms under investigation)
- Use of prescription opioids for any reason within the past 3 months
- Use of prescription corticosteroids for any reason within the past 3 months
- Free of acute viral or bacterial infection, or recent infection within the last 14
days or still requiring prescription medication for treatment
- Free of recent acute trauma occurring within the last 14 days
- Currently or recently (within last 14 days) taking any dietary supplements containing
xanthohumol flavonoids, or other known herbal "anti-inflammatories" including:
curcumin, turmeric, fenugreek, hops, rosemary, ginger, white willow, Devil's claw,
fish oil (doses>1 g/day), or quercetin. Candidates will be given the option to "wash
out" for 14 days and re-contact the study team.
- Currently receiving intravenous nutrition support therapy (or within the last 30 days)
- Currently taking anti-coagulant or anti-platelet prescription medications (or they
were taken within the last 30 days)
- Currently taking antibiotic, antiparasitic, or antifungal medications orally or
intravenously (or they were taken within the last 30 days)
- Initiation of or changes to supplements or medications within 30 days prior to
screening
- Initiation of or changes to an exercise regimen within 30 days prior to screening
- Initiation of or changes to a food plan within 30 days prior to screening
- Current involvement or within 30 days prior to screening of a significant diet or
weight loss program, such as NutriSystem, Jenny Craig, Atkin's or other low-carb diet
programs, or very low-calorie liquid diet programs (such as optifast, medifast, and/or
HMR)
- Hospitalization (for any reason other than an elective medical procedure) within 3
months prior to screening
- Gastrointestinal surgery within 3 months prior to screening
- Undergoing UV therapy (e.g. treatment for skin conditions such as psoriasis).
- Engaging in vigorous exercise more than 6 hours per week.
- Women who are lactating, pregnant or planning pregnancy within the next four months
- Typical intake of more than 2 alcohol-containing beverages per day, more than 14 per
week, or more than 4 in any single day within the past 28 days
- Use of recreational drugs/substances (such as but not limited to cocaine,
phencyclidine (PCP), and methamphetamine) within 30 days of screening
- Currently participating in another interventional research study or participated in
another interventional study within 30 days of screening
common.study.methods.has-drugs-yes
common.study.methods.is-healthy-no
