Eligibility Details:
Participants in the Phase 1 Screening
Inclusion criteria:
In order to be eligible to participate in this study, an individual must meet all of the
following criteria:
- 18 and older (enrollment at most sites will be restricted to 30 and older since this
demographic has the highest prevalence of infection; however, individuals and/or
partners of someone with an HPV-related cancer, for example, are at increased risk so
will be enrolled in the larger age range).
- Willing to be contacted to arrange follow-up visits, if determined to be eligible for
phase 2
- Ability to understand and the willingness to sign a written informed consent document
In addition, individuals must meet at least one of the following criteria:
- Male, aged 30 and older, with 2 or more lifetime oral sex
- History of anal or genital dysplasia or cancer
- Partners of someone with an HPV-related cancer (HPV-positive OPC, anal cancer or
genital cancer)
- Known oncogenic HPV-positive biomarker from prior studies or testing, regardless of
number of partners.
Exclusion criteria:
An individual who meets any of the following criteria will be excluded from participation
in this study:
- Presence of medical or psychiatric condition affecting ability to give voluntary,
informed consent.
- Participants who do not speak English cannot enroll because the consent and study
survey are only available in English. However, if there is a hearing, literacy or
minor fluency issue and the participant requests assistance from a family member or
the study coordinator, this individual may still enroll and receive this assistance to
ensure they fully hear and understand everything being asked.
- History of head and neck cancer
Participants in the Phase 2 Follow-Up
Inclusion criteria:
- Oncogenic oral HPV infection and/or HPV serum oncogenic antibodies detected in phase 1
- Willingness to complete annual follow up visits
Exclusion criteria:
• Unable to complete annual follow up visits