common.study.topics.clinical

Role of Sweetness in Glucose Regulation

common.study.values.description

Role of Sweetness in Glucose Regulation

Data from several studies show that consuming a diet high in low-calorie sweeteners (LCS), mainly in diet sodas, is linked to the same metabolic disorders as consuming a diet high in added sugars, including an increased risk of developing type 2 diabetes. Sweet taste receptors, once thought to be unique to the mouth, have now been discovered in other parts of the body, including the intestine and the pancreas, where they play a role in blood sugar control. These newly identified receptors provide new avenues to explore how LCS may affect metabolism and health. This project is designed to examine the role of sweet taste signaling, both in the mouth and in the gut, on blood sugar control and how habitual consumption of LCS may affect sweet taste signaling and metabolism in people with obesity.

common.study.values.location

participant.ui.study.affiliations-map.online-study.header-virtual

participant.ui.study.affiliations-map.online-study.text

participant.ui.study.affiliations-map.legend.locations participant.ui.study.affiliations-map.legend.selected

common.study.values.methods

No pharmaceutical medication involved common.study.methods.has-drugs-no
Patients and healthy individuals accepted common.study.methods.is-healthy-no

Control - Inhibition

Taste and spit up water 10 minutes before drinking a glucose load

Experimental I- Inhibition

Taste and spit up water 10 minutes before drinking a glucose load mixed with lactisole

Experimental II- Inhibition

Taste and spit up sucralose 10 minutes before drinking a glucose load mixed with lactisole

Control- Stimulation

Taste and spit up water 10 minutes before drinking a glucose load

Experimental I- Stimulation

Taste and spit up sucralose 10 minutes before drinking a glucose load

Experimental II- Stimulation

Drink sucralose 10 minutes before drinking a glucose load

Sensory Evaluation

Taste different solutions to evaluate sweet taste preference, suprathreshold intensity and detection threshold

participant.views.study.view.additional

participant.views.study.view.scientific-title

Role of Sweet Taste Signaling in Glucose Regulation

common.study.values.clinical-trial-id

NCT03844230

participant.views.study.view.id

b4xKgb