Role of Sweetness in Glucose Regulation
common.study.values.description
“Role of Sweetness in Glucose Regulation”
Data from several studies show that consuming a diet high in low-calorie sweeteners (LCS), mainly in diet sodas, is linked to the same metabolic disorders as consuming a diet high in added sugars, including an increased risk of developing type 2 diabetes. Sweet taste receptors, once thought to be unique to the mouth, have now been discovered in other parts of the body, including the intestine and the pancreas, where they play a role in blood sugar control. These newly identified receptors provide new avenues to explore how LCS may affect metabolism and health. This project is designed to examine the role of sweet taste signaling, both in the mouth and in the gut, on blood sugar control and how habitual consumption of LCS may affect sweet taste signaling and metabolism in people with obesity.
common.study.values.location
participant.ui.study.affiliations-map.online-study.header-virtual
participant.ui.study.affiliations-map.online-study.text
common.study.values.methods
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common.study.methods.is-healthy-no
Control - Inhibition
Taste and spit up water 10 minutes before drinking a glucose load
Experimental I- Inhibition
Taste and spit up water 10 minutes before drinking a glucose load mixed with lactisole
Experimental II- Inhibition
Taste and spit up sucralose 10 minutes before drinking a glucose load mixed with lactisole
Control- Stimulation
Taste and spit up water 10 minutes before drinking a glucose load
Experimental I- Stimulation
Taste and spit up sucralose 10 minutes before drinking a glucose load
Experimental II- Stimulation
Drink sucralose 10 minutes before drinking a glucose load
Sensory Evaluation
Taste different solutions to evaluate sweet taste preference, suprathreshold intensity and detection threshold
participant.views.study.view.additional
participant.views.study.view.scientific-title
Role of Sweet Taste Signaling in Glucose Regulation
common.study.values.clinical-trial-id
NCT03844230
participant.views.study.view.id
b4xKgb
