Dyspnea Assessment in Hemodialysis Patients

Dyspnea Assessment in Hemodialysis Patients

Shortness of breath is very common among patients on dialysis for kidney failure; however, its causes are often not understood. This study will explore the lungs and the heart of these patients to determine the causes of shortness of breath. The amount of salt in the body tissues, which tends to accumulate in dialysis patients and can also cause shortness of breath, will also be measured. Machines that exploit magnetic resonance, ultrasound and x-rays to take images of the body interior will be employed; in addition, breathing tests, questionnaires and blood tests will also be used. 20 patients on dialysis will be recruited and have two visits: one at the beginning of the study and one year later to observe any changes in the lungs, heart and salt accumulation over time.

No pharmaceutical medication involved
Recruiting patients only

Diagnostic Test - Echocardiography

Transthoracic 2D Speckle-Tracking Echocardiography

Diagnostic Test - Fractional Exhaled Nitric Oxide

Fractional Exhaled Nitric Oxide testing

Diagnostic Test - Pulmonary Function Tests

Spirometry and Plethysmography

Diagnostic Test - Six-Minute Walk Test

Six-Minute Walk Test

Diagnostic Test - Blood Sampling

Blood testing for: standard-of-care, inflammatory biomarkers, uremic toxins

Diagnostic Test - Lung MRI

Proton Lung Magnetic Resonance Imaging

Diagnostic Test - Sodium MRI

Sodium Soft Tissue Magnetic Resonance Imaging

Diagnostic Test - Chest CT

High-resolution Quantitative Chest CT

Diagnostic Test - Dyspnea Questionnaires

Modified Medical Research Council; University of California, San Diego Shortness of Breath Questionnaire; Borg Scale

Multimodal Assessment of Dyspnea, Cardiopulmonary Structure and Function in Chronic Hemodialysis Patients