Testing Experimental Medication in Healthy Subjects

Trial of Indole-3-Carbinol and Silibinin

This is a non-therapeutic, Phase 1 clinical trial to examine the safety, pharmacokinetic (PK) characteristics, and pharmacodynamics (PD) effect of indole-3-carbinol (I3C) and silibinin (Sil) in healthy subjects.

Pharmaceutical medication involved
Patients and healthy individuals accepted

Drug - Indole-3-Carbinol

Cohorts 2, 3, & 4: 400 mg PO BID

Drug - Silibinin

Cohorts 1 & 4: 720mg

Drug - Silibin

Cohort 3: 360mg

Trial of Indole-3-Carbinol & Silibinin