common.study.topics.clinical

Perioperative Lidocaine and Ketamine in Abdominal Surgery

common.study.values.description

Perioperative Lidocaine and Ketamine in Abdominal Surgery

The investigators propose to test the hypothesis that perioperative infusions of lidocaine and/or ketamine reduce opioid consumption and pain scores in adults recovering from elective inpatient abdominal surgery.

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Pharmaceutical medication involved common.study.methods.has-drugs-yes
Patients and healthy individuals accepted common.study.methods.is-healthy-no

Drug - Lidocaine and ketamine

Perioperative lidocaine and ketamine infusion (see below for dosages and timings)

Drug - Lidocaine

Perioperative lidocaine infusion (1.5 mg/kg bolus followed by an infusion of 2 mg/kg/hour based on actual body weight; the bolus and infusion will be started after anesthesia induction and before surgical incision, and continued until 1 hour after transfer from the operating room to the PACU)

Drug - Ketamine

Perioperative ketamine infusion (0.5 mg/kg bolus followed by an infusion of 0.3 mg/kg/hour based on actual body weight; the bolus and infusion will be started after anesthesia induction and before surgical incision, and continued until 1 hour after transfer from the operating room to the PACU)

Drug - Placebo

Perioperative placebo infusion (normal saline)

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Lidocaine and Ketamine in Abdominal Surgery

common.study.values.clinical-trial-id

NCT04084548

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bW6Jva