Synaptic Density in Psychiatric Disorders

SV2 PET Imaging With [11C]APP311

The aim of this study is to evaluate a new SV2A tracer, [11C]APP311, in healthy aging and neuropsychiatric disorders including psychotic disorders and cannabis use disorders.

No pharmaceutical medication involved
Patients and healthy individuals accepted

Radiation - [11C]APP311

It has been shown that [11C]APP311 (aka [11C]UCB-J) displays high specificity and selectivity for the synaptic vesicle protein SV2A. Since this protein is expressed ubiquitously in active synapses, this tracer has the potential to be a general purpose tool for quantitative imaging of synaptic density.

Synaptic Density in Psychiatric Disorders Using SV2A Receptor PET Imaging With [11C]APP311