Mechanism of Action of Electroconvulsive Therapy

Eligibility Details: Inclusion Criteria: - Males and Females Between Ages of 18 and 65 - Diagnosis of Major Depressive Disorder without Psychotic Features or Bipolar I/II - Requiring ECT Treatment as Part of Psychiatric Care Exclusion Criteria: - Comorbid diagnoses of Major Depressive Disorder with Psychotic Features, Schizoaffective Disorder, Schizophrenia or Dementia - History of Psychosis - Substance Use Disorder (Abuse or Dependence) with Active Use Within Last 6 Months - Severe or Unstable Medical Illness - Medical Contraindication to Anesthesia or ECT (e.g., Recent Myocardial Infarction)