Eligibility Details:
Inclusion Criteria:
- Biologically female
- Ages 18-45
- Presence of primary dysmenorrhea
- Has a 'smart' phone and is willing to download and use an electronic application for
use during the study.
- Willing to take a non-hormonal form of birth control throughout the trial period
(abstinence, condom, diaphragm, or copper IUD (ParaGard))
- Lives in the Portland area
- Able to speak, read and write English
- Has reliable transportation to clinic
- Willing to have four fasting blood draws taken
- Wiling to collect menstrual fluid in a Diva© cup on the first day of menstruation and
ability to deliver it to the clinic on the same day
- Ability to receive and complete electronic VAS scales
- Pain scale rating of 6 or higher on the VAS scale
- Monthly pain that correlates with menstruation
Exclusion Criteria:
- Presence of secondary dysmenorrhea
- General health measures outside of normal range:
- Blood pressure readings obtained at the Screening Visit reveal hypotension
(≤90/60 mmHg) or hypertension (≥140/90 mmHg).
- Aspartate aminotransferase (AST) < 8 U/L or > 48 U/L at the Screening Visit.
- Alanine aminotransferase (AST) < 7 U/L or > 55 U/L at the Screening Visit.
- Estimated glomerular filtration rate (eGFR) < 90 ml/min/1.73m2 at the Screening
Visit.
- An INR value > 1.1 at the Screening Visit.
- A red blood cell count < 3.90 million cells/mcL or > 5.03 million cells/mcL.
- A hemoglobin value of < 12 g/dL (120 g/L) or > 15.5 g/dL (155 g/L).
- A hematocrit value of < 34.9% or > 44.5%.
- A white blood cell count < 3.5 billion cells/L (3,500 cells/mcL) or > 10.5
billion cells/L (10,500 cells/mcL)
- A platelet count < 150 billion/L (150,000/mcL) or > 450 billion/L (450,000 mcL).
- Women who are nursing, pregnant, or planning pregnancy in the next four months
- Difficulty swallowing or aversion to capsules, tablets, or pills
- Currently taking, and unwilling to discontinue, NSAIDs (Aspirin, Ibuprofen)
- Currently taking dietary supplements with any of the following ingredients in amounts
over 250 mg/day: cinnamon, garlic, ginger, turmeric, and/or curcumin
- Consumption of >1 alcoholic drink per day, during the study period
- Currently taking any anticoagulation medications (Warfarin/Coumadin)
- Currently taking, or have taken in the past two months, hormonal forms of birth
control
- Unwillingness, or inability, to take a monthly pregnancy test during the timeline of
the study (3 pregnancy tests)
- Past or present medical history of any of the following:
- Blood clotting disorders (von Willebrand disease, Hemophilia A, Hemophilia B,
etc.)
- Liver disease (cirrhosis, hepatitis, liver failure, jaundice, liver cancer, etc.)
- Kidney disease (chronic kidney disease, polycystic kidney disease, etc.)
- Cardiac disease (hypertension, heart failure, cardiomyopathy, etc.)
- Anemia (iron deficiency, sickle cell, aplastic, etc.)
- Inflammatory bowel disease
- Irritable bowel syndrome
- Endometriosis
- Obstructive endometrial polyps
- Chronic pelvic inflammatory disease
- Polycystic Ovarian Syndrome
- Adenomyosis
- Intrauterine or pelvic adhesions
- Congenital obstructive mullerian malformations
- Cervical stenosis
- Use of an intrauterine contraceptive device that causes pain
- Pelvic congestion syndrome
- Reproductive cancer (uterine cancer, ovarian cancer, endometrial cancer, etc.)
- Ovarian cysts
- Fibroids
- Uteropelvic junction obstruction
common.study.methods.has-drugs-no
common.study.methods.is-healthy-no
