Transcranial Magnetic Stimulation in Healthy Volunteers

Establishing Functional Biomarkers for Spaced Theta-Burst Stimulation

The investigators plan to use functional magnetic resonance imaging (fMRI) methods to assess brain changes following spaced theta burst stimulation (TBS), a new form of repetitive transcranial magnetic stimulation (rTMS), in 10 healthy participants. The investigators will measure the effects of both excitatory (intermittent, iTBS) and inhibitory (continuous, cTBS) TBS applied to the motor cortex, a system that when stimulated produces a readily observable behavioral response (e.g., movement of a given body regions). In addition to brain activity, we will assess the effects of TBS on motor responses and pain perception. The goal is to determine how brain activity and blood flow during tasks and at rest change following the applications of spaced cTBS and iTBS. Additionally, the aim is to determine the duration of the spaced TBS effects on brain activity and behavior. This study will provide an understanding of the functional brain and behavioral changes that occur following spaced TBS to the motor cortex and has implications for reducing the long treatment schedules associated with classical rTMS protocols.

No pharmaceutical medication involved
Patients and healthy individuals accepted

Device - continuous Theta Burst Stimulation

Continuous Theta Burst Simulation will be applied in a continuous manner resulting in cortical excitability.

Device - intermittent Theta Burst Stimulation

Intermittent Theta Burst Stimulation will be applied in an intermittent manner resulting in cortical inhibition.

Establishing Functional Biomarkers for Spaced Theta-Burst Stimulation