Treatment for Methamphetamine-Use Disorder

Behavioral Effects of Drugs (Inpatient): 40 [Methamphetamine, Methylphenidate, Duloxetine]

This study will evaluate the behavioral effects of methamphetamine during maintenance on placebo, duloxetine, methylphenidate and duloxetine combined with methylphenidate using sophisticated human laboratory methods.

Pharmaceutical medication involved
Patients and healthy individuals accepted

Drug - Methamphetamine

In each arm, subjects will receive doses of methamphetamine.

Drug - Methylphenidate

In each arm, subjects will receive methylphenidate capsules.

Drug - Placebo oral capsule

In each arm, subjects will receive placebo capsules.

Drug - Duloxetine

Subjects will receive duloxetine capsules in the duloxetine arm.

A Novel Drug Combination as a Pharmacotherapeutic for Methamphetamine-Use Disorder