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Dietary Intervention in ADPKD on Tolvaptan

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Dietary Intervention in ADPKD on Tolvaptan

Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited renal disorder. Tolvaptan has been approved in Canada as a treatment for ADPKD. Tolvaptan is an arginine vasopressin receptor antagonist which has been shown to decrease the progression of ADPKD. The main side effect of this treatment is increased urine output which leads to cessation of therapy in about 20% of patients. Low solute (low sodium, low protein) diet may alleviate this side effect. This is a single arm before / after study of dietary intervention on urine output and quality of life in ADPKD patients on a stable dose of tolvaptan.

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participant.ui.study.affiliations-map.online-study.header-virtual

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No pharmaceutical medication involved common.study.methods.has-drugs-no
Recruiting patients only common.study.methods.is-healthy-yes

Dietary

Low sodium, low protein dietary recommendation

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Dietary Intervention in Patients With ADPKD on Tolvaptan: Urine Output and Quality of Life

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NCT03858439

participant.views.study.view.id

dPNKya