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Mometasone Nasal Irrigation for Chronic Rhinosinusitis

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Effectiveness of Mometasone Nasal Irrigation for Chronic Rhinosinusitis

Chronic rhinosinusitis (CRS) affects up to 12.5% of the US population and has a significant disease burden. The recommended medical management of CRS includes large-volume, low-pressure saline lavage, systemic antibiotics, and intranasal corticosteroids (INCS). While the efficacy and safety of INCS are well-established for the long-term management of CRS, penetration of INCS beyond the nasal vestibule and into the paranasal sinuses is limited. The aim of this study is to evaluate the effectiveness of mometasone furoate large-volume, low-pressure nasal irrigation for surgery-naive CRS patients.

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Pharmaceutical medication involved common.study.methods.has-drugs-yes
Patients and healthy individuals accepted common.study.methods.is-healthy-no

Drug - Mometasone Furoate Nasal Irrigation

Participants will undergo an 8-week treatment course that includes nasal saline irrigation with mometasone powder and placebo nasal spray.

Drug - Mometasone Nasal Spray

Participants will undergo an 8-week treatment course that includes placebo saline irrigation with mometasone nasal spray.

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Effectiveness of Mometasone Nasal Irrigation for Chronic Rhinosinusitis

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NCT03705793

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