Sensory Evaluation of the Taste of Pediatric Medicines
“Sensory Evaluation of the Taste of Pediatric Medicines”
The investigators will conduct a systematic study of the sensory perception of a diverse set of commonly used pediatric liquid medications and excipients in tandem with an equally complete genetic analysis of the adult sensory panelists to investigate the relationship between genetic variation and individual differences in the perceived flavor (taste, smell, irritation) of pediatric medicines. The flavor of each medicine and excipient will be measured individually using both cognitively demanding methods unsuitable for young children and simpler measures validated for use by children. Salivary DNA samples will be collected to carry out genome wide association study (GWAS).
Taste of Medicines for Children: Genetic Variation and Medical Adherence (Aim 1)