Deep rTMS and Varenicline for Smoking Cessation
Study Description
“Deep rTMS and Varenicline for Smoking Cessation”
The purpose of this study is to investigate the effect of deep repetitive transcranial magnetic stimulation (rTMS) using the insula H-coil on smoking outcomes in smokers receiving varenicline. It is hypothesized that active deep rTMS will improve abstinence rates, attenuate craving and reduce cigarette consumption and dependence severity.
Location
Methods
Pharmaceutical medication involved
Recruiting patients only
Device - Deep Repetitive Transcranial Magnetic Stimulation (Active)
Active deep rTMS (10 Hz) using the H-coil to target the bilateral insula
Device - Deep Repetitive Transcranial Magnetic Stimulation (Sham)
Sham deep rTMS using the H-coil. The sham coil is built into the same helmet as the active coil. It mimics the active coil with regards to acoustics and scalp sensations.
Drug - Varenicline
12 week course treatment of varenicline (0.5 mg/1 mg) using the standard dosage schedule for smoking cessation (Day 1-3: 0.5 mg daily; day 4-7: 0.5 mg twice a day; day 8-end of treatment: 1 mg twice a day).
Additional Information
Official Study Title
Deep rTMS and Varenicline for Smoking Cessation: A Pilot Study Exploring the Efficacy of a Combined Treatment Approach
Clinical Trial ID
NCT04083144
ParticipAid ID
dPNyWa
