“Induction of Gut Permeability by an Oral Vaccine”
This study evaluates the effect of an oral typhoid vaccine on disruption of the intestinal barrier and response of the immune system. Intestinal and whole-body responses will be measured in all participants before and after the vaccine.
Biological - Vivotif Typhoid Oral Vaccine
One capsule is swallowed on alternate days, e.g. days 15, 17, 19, and 21, for a total of 4 capsules.
Drug - Aspirin (Positive Control)
Three tablets (325 mg aspirin in each tablet or 975 mg total) are swallowed on days 2 and 3.
Induction of Gut Permeability by an Oral Vaccine