common.study.topics.clinical

Testing Drug and Vitamin Interaction

common.study.values.description

The Effect of SLC19A3 Inhibition on the Pharmacokinetics of Thiamine

Subjects will be administered thiamine, thiamine with metformin, and thiamine with trimethoprim to determine whether taking a drug and a vitamin together affects the body's ability to absorb, distribute, and eliminate thiamine (Vitamin B1).

common.study.values.location

participant.ui.study.affiliations-map.online-study.header-virtual

participant.ui.study.affiliations-map.online-study.text

participant.ui.study.affiliations-map.legend.locations participant.ui.study.affiliations-map.legend.selected

common.study.values.methods

Pharmaceutical medication involved common.study.methods.has-drugs-yes
Patients and healthy individuals accepted common.study.methods.is-healthy-no

Drug - Trimethoprim

300mg of trimethoprim will be given in combination with 5mg thiamine and compared to 5mg thiamine only

Drug - Metformin

1000mg of metformin will be given in combination with 5mg thiamine and compared to 5mg thiamine only

Dietary Supplement - Vitamin B1

5mg of thiamine will be given alone and in combination

participant.views.study.view.additional

participant.views.study.view.scientific-title

The Effect of SLC19A3 Inhibition on the Pharmacokinetics of Thiamine

common.study.values.clinical-trial-id

NCT03746106

participant.views.study.view.id

e5yARe