Testing Drug and Vitamin Interaction
common.study.values.description
“The Effect of SLC19A3 Inhibition on the Pharmacokinetics of Thiamine”
Subjects will be administered thiamine, thiamine with metformin, and thiamine with trimethoprim to determine whether taking a drug and a vitamin together affects the body's ability to absorb, distribute, and eliminate thiamine (Vitamin B1).
common.study.values.location
participant.ui.study.affiliations-map.online-study.header-virtual
participant.ui.study.affiliations-map.online-study.text
common.study.values.methods
common.study.methods.has-drugs-yes
common.study.methods.is-healthy-no
Drug - Trimethoprim
300mg of trimethoprim will be given in combination with 5mg thiamine and compared to 5mg thiamine only
Drug - Metformin
1000mg of metformin will be given in combination with 5mg thiamine and compared to 5mg thiamine only
Dietary Supplement - Vitamin B1
5mg of thiamine will be given alone and in combination
participant.views.study.view.additional
participant.views.study.view.scientific-title
The Effect of SLC19A3 Inhibition on the Pharmacokinetics of Thiamine
common.study.values.clinical-trial-id
NCT03746106
participant.views.study.view.id
e5yARe
